Glucose Control In Severely Thermally Injured Pediatric Patients: What Glucose Range Should Be The Target?
*Marc G Jeschke, *Robert Kraft, *Fatemeh Emdad, *Gabriela A Kulp, *Felicia N Williams, David N Herndon
UTMB, Galveston, TX
OBJECTIVE(S): Tight euglycemic control was rapidly implemented in ICUs around the world, but there is increasing evidence that tight euglycemic control is associated with detrimental outcomes. Currently, no study exists that indicates which glucose range should be targeted. The objective of this study was to determine which glucose levels are associated with improved morbidity and mortality in thermally injured patients.
METHODS: Two-hundred eight severely burned pediatric patients with burns over 30% of their total body surface area (TBSA) were included in this trial. Several statistical models were used to determine the daily average and 6 a.m. glucose target that were associated with improved morbidity and mortality. Patients were then divided into good glucose controlled and poor glucose controlled patients and demographics, clinical outcomes, infection, sepsis, inflammatory and hypermetabolic responses were determined.
RESULTS: Statistical modeling showed that hyperglycemia is a strong predictor of adverse hospital outcome and that daily 6 a.m. glucose level of 130 mg/dl and daily average glucose levels of 140 mg/dl are associated with improved morbidity and mortality postburn. When patients were divided into good glucose control and poor glucose control we found that patients with glucose levels of 130 mg/dl exert attenuated hypermetabolic and inflammatory responses, as well as significantly lower incidence of infections, sepsis, and mortality compared to patients with poor glucose control, p<0.05.
CONCLUSIONS: Given the controversy over glucose range, glucose target, and risks and detrimental outcomes associated with hypoglycemia we suggest that in severely burned patient’s blood glucose of 130 mg/dl should be targeted.